Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis
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Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis
Glomerular permeability and subsequent albuminuria are early clinical markers for glomerular injury in hypertensive nephropathy. Albuminuria predicts mortality and cardiovascular morbidity. AT1 receptor blockers protect from albuminuria, cardiovascular morbidity and mortality. A blood pressure independent, molecular mechanism for angiotensin II (Ang II) dependent albuminuria has long been postu...
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asynchrony were highly restrictive and may have led to selection of patients with a very unfavorable prognosis. Fourth, we agree with Dr. Gasparini and colleagues that the screening of patients suitable for CRT based on merely clinical criteria may be sufficient in specific settings. However, we are of the opinion that this simplification could increase the number of non-responders to CRT: this...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep39513